Table 4.

Multivariate analyses of DFS (Backward Stepwise, Likelihood Ratio)

Variable	HR	95 % CI	P value
Tumor size	0.954	0.636 to 1.432	0.821
(≤2 cm vs >2 cm)
Skin involvement
(No vs Yes)	1.211	0.752 to 1.950	0.431
LN metastasis	2.054	1.398 to 3.019	0.001
(No vs Yes)
Histologic grade	1.553	1.050 to 2.298	0.028
(≤II vs > II)
ER	0.747	0.496 to 1.125	0.163
(negative vs positive)
TGF-β
(positive vs negative)	0.469	0.301 to 0.729	0.001
PTHRP	1.022	0.684 to 1.527	0.916
(positive vs negative)