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Docking of the δ-COP MHD structure into the AP2 locked/closed form. Surface representation of the AP2 locked form (PDB ID code 2VGL) (21) and docking of the δ-COP MHD (C-δ-COP)-Gcs1p WxxF peptide cocrystal structure into the AP2 locked form based on the superposition of C-δ-COP with C-μ2. The Gcs1p WxxF peptide is shown as spheres. Note the significant occlusion of the Yxxϕ binding site in μ2 in the AP2 structure and the fully accessible WxxF binding site in δ-COP.
