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. 2015 Nov 2;112(46):E6359–E6368. doi: 10.1073/pnas.1516394112

Fig. 1.

Fig. 1.

Reduced expression of DOCK4 in MDS correlates with anemia phenotype in patients. (A) Expression of DOCK4 is significantly reduced in −7/del(7q) MDS (n = 9) and in the RA (n = 55) subtype of MDS. Gene expression profiles were generated from CD34+ cells from MDS patients and controls (n = 17). RA with excess blasts (RAEB; n = 74) and RA with ringed sideroblasts (RARS; n = 48) are other subtypes of MDS (*P < 0.05, Student’s t test). (B) Comparison of gene expression data from sorted acute myeloid leukemia (AML)/MDS bone marrow samples (n = 4) with −7 with healthy controls (n = 4) revealed significantly decreased DOCK4 expression in long-term HSCs (LT-HSC) (*P = 0.01). (C) In the RA patients, lower expression of DOCK4 is significantly associated with worse overall survival [log rank P = 0.045, HR = 3.744 (1.1–12.2)]. Low expression < median expression, high expression > median expression.