Table 2.
This table illustrates the individual change of the mutational profile over time tracked by M3P
| TP 1 | TP 2 | |
|---|---|---|
| FAM46C | 87 % | 83 % |
| KRAS | 57 % | 51 % |
| SP140 | 81 % | 22 % |
| TP53 | 78 % | 90 % |
| 82 % | 0 % | |
| 0 % | 84 % |
Percentage in box represents purity corrected variant reads. In this patient one TP53 mutation gets eradicated over time, whereas a second TP53 mutation expands between the time points, suggesting the presence of at least two different clones. Additionally, a SP140 mutation is decreased but not eradicated, suggesting the existence of a third clone. Furthermore, the mutation frequency of a FAM46C, a KRAS and a third TP53 mutation stay unchanged over time and are not affected by the clonal evolution tracked by M3 P, providing evidence that these mutations are clonal