Table 2.
TP 1 | TP 2 | |
---|---|---|
FAM46C | 87 % | 83 % |
KRAS | 57 % | 51 % |
SP140 | 81 % | 22 % |
TP53 | 78 % | 90 % |
82 % | 0 % | |
0 % | 84 % |
Percentage in box represents purity corrected variant reads. In this patient one TP53 mutation gets eradicated over time, whereas a second TP53 mutation expands between the time points, suggesting the presence of at least two different clones. Additionally, a SP140 mutation is decreased but not eradicated, suggesting the existence of a third clone. Furthermore, the mutation frequency of a FAM46C, a KRAS and a third TP53 mutation stay unchanged over time and are not affected by the clonal evolution tracked by M3 P, providing evidence that these mutations are clonal