Figure 2. Barrier Disruptive and Barrier Protective Pathways of Abl Family Kinases in Endothelial Cytoskeletal Dynamics.

Published data indicated that Abl family kinases play both barrier disruptive (A) and barrier protective (B) roles in cellular signaling pathways that mediate endothelial permeability (details described in text). For the sake of clarity this figure is not drawn to size. S1P – Sphingosine 1-Phosphate, S1PR1 – S1P Receptor 1, MLCK – Myosin Light Chain Kinase, CTTN – Cortactin, VEGF – Vascular Endothelial Growth Factor, VEGFR2 – VEGF Receptor 2, VE-Cad – Vascular Endothelial Cadherin, Vascular Endothelial Cellular Adhesion Molecule 1 – VCAM-1, Protease Activated Receptor 1 – PAR-1, Histamine Receptor 1 (H1), Inositol 3-Phosphate – IP3, IP3 Receptor – IP3R, PLCγ – Phospholipase C Gamma - Reactive Oxygen Species – ROS, Glutathione peroxidase 1 – GPx1, LPS – Lipopolysaccharide, Toll Like Receptor 4 – TLR, H₂O₂ – Hydrogen Peroxide, Ca²⁺ - Calcium, NFκB – Nuclear Factor Kappa B, GPCR – G Protein Coupled Receptor, FA – Focal Adhesion.