Figure 1.

Schematic diagram of the primary sequence of IAPP.

Notes: Black circles indicate the cysteine amino acid C2–C7 disulfide bond. Gray circles indicate amino acid sequences for the hydrophobic regions, with the three aromatic amino acids (F15, F23, and Y37) shown in red. Dashed-circled amino acids are those responsible for amyloid formation.

Abbreviation: IAPP, islet amyloid polypeptide.