Table 5.
Diagnostic performance of liver stiffness and spleen stiffness in detection of esophageal varices in patients with liver cirrhosis
| Liver stiffness | Spleen stiffness | |
|---|---|---|
| Number of patients |
87 |
87 |
| Event prevalence [n (%)] |
54 (62.1) |
54 (62.1) |
| Optimum* cut-off (kPa) |
19.7 |
30.3 |
| Sensitivity (true positive rate) (%) |
83.3 (70.7, 92.1) |
79.6 (66.5, 89.4) |
| Specificity (true negative rate) (%) |
66.6 (48.2, 82.0) |
75.8 (57.7, 88.9) |
| 1-specificity (false positive rate) (%) |
33.4 (18.0, 51.8) |
24.2 (11.1, 42.3) |
| 1-sensitivity (false negative rate) (%) |
16.7 (7.9, 29.3) |
20.4 (10.6, 33.5) |
| Positive predictive value (%) |
80.4 (51.0, 89.8) |
84.3 (71.4, 92.9) |
| Negative predictive value (NPV) (%) |
71.0 (52.0, 85.8) |
69.4 (51.9, 83.6) |
| Event probability – negative test (%) |
29.0 (14.2-48.0) |
30.6 (16.4, 48.1) |
| Likelihood ratio – positive test |
2.5 (1.6, 4.3) |
3.3 (1.9, 6.3) |
| Likelihood ratio – negative test |
0.25 (0.13, 0.46) |
0.27 (0.15, 0.46) |
| Diagnostic odds ratio |
9.7 (3.3, 31.5) |
11.8 (3.9, 39.5) |
| Estimated NPV at 10% prevalence |
97.2 (95.6, 98.4) |
97.1 (95.6, 98.3) |
| Estimated NPV at 20% prevalence |
94.0 (91.6, 95.8) |
93.8 (91.6, 95.6) |
| Estimated NPV at 35% prevalence (as in compensated) | 90.0 (86.7, 91.9) | 87.6 (84.5, 90.2) |
*Optimum combination of sensitivity and specificity.