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Reproducible IISs and IIS-related impedance changes across three seizure models. (A) Simultaneous ECoG (top trace) and dZ signals (bottom trace) recorded from the same electrode. Stable IISs were observed in this electrode shortly after injection of 4-AP, and at each IIS the dZ signal exhibited a fast negative deflection followed by a slower rise and decay. (B–C) Same as (A), but for rats injected with picrotoxin (B) or penicillin (C).
