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. 2015 Nov 16;10:7073–7088. doi: 10.2147/IJN.S94543

Figure 2.

Figure 2

The uptake pathways of different charged QDs in MDA-MB-231 cells.

Notes: The effects of temperature and endocytosis inhibitors on the cellular uptake of QDs were analyzed by confocal fluorescence microscopy (A; 200× magnification) and flow cytometry (B), respectively. MDA-MB-231 Cells were either preincubated at 4°C for 1 hour, followed by incubation with different QDs at 4°C for 2 hours; or pretreated with different endocytosis inhibitors such as amiloride (50 mM), chlorpromazine (CPZ, 10 mg/mL) and filipin III (1 mg/mL) at 37°C for 1 hour, followed by incubation with different QDs at 37°C for 2 hours.

Abbreviations: AMI, amiloride; CA, carboxylic acid; FIL, filipin; PDDA, polydiallydimethylammounium chloride; PEG, polyethylene glycol; QDs, quantum dots.