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. 2015 Nov 16;10:7073–7088. doi: 10.2147/IJN.S94543

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© 2015 Liu et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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In vivo blood clearance and tissue biodistribution.

Notes: In vivo blood clearance (A) and tissue biodistribution (B) of different charged QDs in BALB/c mice after intravenous administration. QDs in the serum were detected by the fluorescence measurement using NanoDrop Fluorospectrometer. The major organs were excised for microscopic examination at 4 hours postinjection. The organ slices (10 µm) were prepared with a cryostat, air-dried for 30 minutes, and fixed with 4% paraformaldehyde for 10 minutes. The nuclei were stained by DAPI (blue), and the signal of QDs (red) was acquired with confocal fluorescence microscopy. Magnification ×200.

Abbreviations: CA, carboxylic acid; DAPI, 4′,6-diamidino-2-phenylindole; PDDA, polydiallydimethylammounium chloride; PEG, polyethylene glycol; QDs, quantum dots.