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. Author manuscript; available in PMC: 2015 Nov 23.
Published in final edited form as: J Pharmacokinet Pharmacodyn. 2015 Sep 3;42(5):463–475. doi: 10.1007/s10928-015-9436-y

Fig. 3.

Fig. 3

An example of inhibition of porcine diamine oxidase (DAO). Experimental data curve fits were obtained through global model nonlinear regression analysis. Metformin inhibition of porcine diamine oxidase is shown [0 mM, (closed circle), 1 mM (open circle), 10 mM (closed square); 40 mM (open square); 90 mM (triangle)]. The overall fit values obtained from three separate experiments were Ki (metformin) = 8.6 ± 3.1 mM; and KM (putrescine) = 0.33 ± 0.16 mM