. Author manuscript; available in PMC: 2015 Nov 23.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2015 Sep 3;42(5):463–475. doi: 10.1007/s10928-015-9436-y

Table 1.

Metformin off-target prediction

Drug	Closest ligand for predicted target	Predicted target	SEA E-value	Closest (max) Tc
		DAO (ABP1)	7.4 × 10⁻⁵	0.35 Tc

Tc Tanimoto coefficient. The Tc calculates the number of on bits in common between fingerprints divided by the total number of nonoverlapping on bits between fingerprints