Table 3.

Invertebrate Model Organism (iMO)–Human Genes: Human Orthologs of Genes that Influence Alcohol-Related Behaviors in iMOs

Human gene	iMO source	Human gene	iMO source	Human gene	iMO source	Human gene	iMO source	Human gene	iMO source	Human gene	iMO source
ABCG2	Fly	CLIC1	Fly, Worm	FGFR4	Fly	LMO1	Fly	PIK3CD	Fly	SLC6A3	Fly
ACSS1	Fly	CLIC2	Fly, Worm	FOXO1	Fly	LMO2	Fly	PIK3CG	Fly	SLC9A3R1	Fly
ACSS2	Fly	CLIC3	Fly, Worm	FOXO3	Fly	LMO3	Fly	PIK3R1	Fly	SLC9A3R2	Fly
ACTL6A	Worm	CLIC4	Fly, Worm	FOXO4	Fly	LTK	Fly	PIK3R2	Fly	SMARCA2	Worm
ACTL6B	Worm	CLIC5	Fly, Worm	FOXO6	Fly	MADD	Worm	PIK3R3	Fly	SMARCA4	Worm
ADCY1	Fly	CLIC6	Fly, Worm	FST	Fly	MAP4K1	Fly	PPIA	Fly	SMARCC1	Worm
ADH1A	Fly, Worm	COX6C	Fly	FSTL3	Fly	MAP4K2	Fly	PPIF	Fly	SMARCC2	Worm
ADH1B	Fly, Worm	CRYAA	Fly	GABBR1	Fly	MAP4K3	Fly	PRAF2	Fly	SMARCD1	Worm
ADH1C	Fly, Worm	CRYAB	Fly	GAD1	Worm	MAP4K5	Fly	PRKACA	Fly	SMARCD2	Worm
AKT1	Fly	CSAD	Worm	GAD2	Worm	MAPK1	Fly	PRKACB	Fly	SMARCD3	Worm
AKT2	Fly	CSNK1A1	Fly	GADL1	Worm	MAPK10	Fly	PRKACG	Fly	SMARCE1	Worm
AKT3	Fly	CSNK1D	Fly	GFI1	Worm	MAPK3	Fly	PRKAR2A	Fly	SREBF1	Worm
ALDH family (19 genes)	Worm	CSNK1E	Fly	GFI1B	Worm	MAPK8	Fly	PRKAR2B	Fly	SREBF2	Worm
		CTBP1	Worm	GPC1	Fly	MAPK9	Fly	PRKCE	Fly	STX1A	Fly
ALK	Fly	CTBP2	Worm	GPC2	Fly	MARK1	Fly	PRKCH	Fly	STX1B	Fly
ARF6	Fly	DBH	Fly	GPC3	Fly	MARK2	Fly	PSMD1	Fly	STX2	Fly
ARFIP1	Fly	DGKQ	Worm	GPC4	Fly	MARK3	Fly	PTEN	Fly	STX3	Fly
ARFIP2	Fly	DLG1	Fly	GPC5	Fly	MARK4	Fly	RAB3A	Worm	STX4	Fly
ARID1A	Worm	DLG2	Fly	GPC6	Fly	ME1	Fly	RAB3B	Worm	STXBP1	Worm
ARID1B	Worm	DLG3	Fly	GPR84	Fly	ME2	Fly	RAB3C	Worm	STXBP2	Worm
ARID2	Worm	DLG4	Fly	GRIN1	Fly	ME3	Fly	RAB3D	Worm	STXBP3	Worm
ARL6IP5	Fly	DNM1	Fly	HNF4A	Worm	MFNG	Fly	RAC1	Fly	SYN1	Fly
ARNTL	Fly	DNM2	Fly	HNF4G	Worm	MTNR1A	Fly	RAC2	Fly	SYN2	Fly
ARNTL2	Fly	DNM3	Fly	HOMER1	Fly	MTNR1B	Fly	RAC3	Fly	SYN3	Fly
ATP12A	Worm	DPF1	Worm	HOMER2	Fly	MYL1	Fly	RFNG	Fly	TAF4	Fly
ATP1A1	Worm	DPF2	Worm	HOMER3	Fly	MYL3	Fly	RHBDL1	Fly	TAF4B	Fly
ATP1A2	Worm	DPF3	Worm	HPGD	Fly	MYL4	Fly	RHBDL2	Fly	TAOK1	Fly
ATP1A3	Worm	DRD1	Fly, Worm	IGF1R	Fly	MYL6	Fly	RHBDL3	Fly	TAOK2	Fly
ATP1A4	Worm	DRD5	Fly	INSR	Fly	MYL6B	Fly	RHEB	Fly	TAOK3	Fly
ATP4A	Worm	DUSP10	Fly	INSRR	Fly	NALCN	Worm	RHEBL1	Fly	TBX20	Fly
AUTS2	Fly	EGFR	Fly	IRS1	Fly	NAT10	Fly	RHOA	Fly	TH	Worm
BBS1	Worm	EI24	Fly	IRS2	Fly	NCAM1	Fly	RHOB	Fly	TIMELESS	Fly
BRD7	Worm	EPS8	Fly	IRS4	Fly	NCAM2	Fly	RHOC	Fly	TPH1	Worm
BRD9	Worm	EPS8L1	Fly	ITGB1	Fly	NPY	Fly	SCAP	Fly	TPH2	Worm
CASK	Fly	EPS8L2	Fly	ITGB2	Fly	NPY1R	Fly, Worm	SDC1	Fly	TRPV1	Fly, Worm
CDC42	Fly	EPS8L3	Fly	ITGB3	Fly	NPY2R	Fly, Worm	SDC2	Fly	TRPV2	Fly, Worm
CHAT	Worm	ERBB2	Fly	ITGB5	Fly	NPY4R	Fly, Worm	SDC3	Fly	TRPV3	Fly, Worm
CHP1	Fly	ERBB3	Fly	ITGB7	Fly	PBRM1	Worm	SDC4	Fly	TRPV4	Fly, Worm
CHP2	Fly	ERBB4	Fly	KCNMA1	Fly, Worm	PCSK2	Worm	SGK1	Fly	TRPV5	Fly, Worm
CHRNA1	Worm	FADS1	Worm	KCNQ1	Fly	PDPK1	Fly	SGK2	Fly	TRPV6	Fly, Worm
CHRNA2	Worm	FADS2	Worm	KCNQ2	Fly	PER1	Fly	SIRT1	Fly, Worm	UGDH	Fly
CHRNA3	Worm	FADS3	Worm	KCNQ3	Fly	PER2	Fly	SIRT3	Worm	UNC13A	Fly
CHRNA4	Worm	FBRSL1	Fly	KCNQ4	Fly	PER3	Fly	SLC18A1	Worm	UNC13B	Fly
CHRNA6	Worm	FGFR1	Fly	KCNQ5	Fly	PHF10	Worm	SLC18A2	Worm	UNC13C	Fly
CHRNB2	Worm	FGFR2	Fly	KCNU1	Fly, Worm	PIK3CA	Fly	SLC32A1	Worm	UNC79	Worm
CHRNB4	Worm	FGFR3	Fly	LFNG	Fly	PIK3CB	Fly	SLC6A2	Fly	UNC80	Worm

Columns are the human orthologs of genes originally identified in the iMO source indicated (fly, Worm, or both).