Table 2.
Nerve conduction and cardiovascular autonomic neuropathy measures at baseline, 12 and 18 months of follow-up
| Variable | Baseline | P | 12 months | P | 18 months | P | Difference: Baseline to 18 months | P |
|---|---|---|---|---|---|---|---|---|
| Median Motor Amplitude (mV) | ||||||||
| Exenatide | 9.9±3.6 | 0.09 | 9.1±3.4 | 0.29 | 9.2±3.6 | 0.12 | −0.2±1.8 | 0.49 |
| Glargine | 8.3±2.9 | 7.9 ±3.1 | 7.7 ±2.5 | −0.5±2.6 | ||||
| Median Motor CV (m/sec) | ||||||||
| Exenatide | 49.8±4.6 | 0.63 | 48.7±4.8 | 0.55 | 49.4±5.2 | 0.65 | −0.4±4.6 | 0.37 |
| Glargine | 50.5±4.4 | 49.6±4.7 | 48.5±6.9 | −1.9±5.7 | ||||
| Median Motor F Response Latency (msec) | ||||||||
| Exenatide | 30.9±2.7 | 0.85 | 30.6±2.3 | 0.59 | 31.6±3.2 | 0.71 | 0.5±2.4 | 0.94 |
| Glargine | 31.1±2.8 | 31.1±3.2 | 31.2±3.5 | 0.2±1.7 | ||||
| Median Sensory Amplitude (μV) | ||||||||
| Exenatide | 15.5±12.7 | 0.51 | 15.0±10.9 | 0.44 | 14.3±10.7 | 0.59 | −1.6±5.8 | 0.71 |
| Glargine | 13.3±8.8 | 12.6±8.0 | 12.6±9.1 | −0.7±5.2 | ||||
| Median Sensory CV (m/sec) | ||||||||
| Exenatide | 45.0±12.5 | 0.27 | 43.8±13.6 | 0.57 | 44.9±13.6 | 0.54 | −0.03±9.5 | 0.62 |
| Glargine | 41.1±11.2 | 41.7±10.2 | 42.5±11.1 | 1.3±5.8 | ||||
| Peroneal Motor Amplitude (mV) | ||||||||
| Exenatide | 3.9±1.9 | 0.30 | 3.7±1.9 | 0.82 | 3.8±1.8 | 0.59 | −0.3±1.6 | 0.29 |
| Glargine | 3.3±2.3 | 3.9±2.7 | 3.5±2.4 | 0.2±1.5 | ||||
| Peroneal Motor CV (m/sec) | ||||||||
| Exenatide | 40.4±4.6 | 0.19 | 39.6±5.5 | 0.20 | 39.9±6.0 | 0.39 | −0.3±4.4 | 0.97 |
| Glargine | 38.2±6.2 | 37.4±5.6 | 38.4±5.9 | 0.1±4.8 | ||||
| Peroneal Motor F Response Latency (msec) | ||||||||
| Exenatide | 53.0±13.2 | 0.03 | 58.3±7.6 | 0.94 | 55.7±6.8 | 0.37 | 3.2±14.4 | 0.14 |
| Glargine | 60.2±7.3 | 58.1±9.7 | 57.7±8.2 | −2.5±8.9 | ||||
| Sural Sensory Amplitude (μV) | ||||||||
| Exenatide | 7.0±7.0 | 0.27 | 6.2±7.5 | 0.76 | 5.8±6.4 | 0.46 | −1.5±3.0 | 0.35 |
| Glargine | 5.0±4.8 | 5.6±5.6 | 4.52±4.4 | −0.5±2.6 | ||||
| Sural Sensory CV (m/sec) | ||||||||
| Exenatide | 41.0±6.7 | 0.98 | 39.2±6.2 | 0.30 | 39.2±5.3 | 0.84 | −1.4±5.6 | 0.39 |
| Glargine | 40.9±7.1 | 41.7±9.2 | 38.8±5.6 | −2.0±4.7 | ||||
| HR, beat/min | ||||||||
| Exenatide | 70±12 | 0.21 | 69±10 | 0.11 | 70±9 | 0.07 | 1±12 | 0.80 |
| Glargine | 74±8 | 74±9 | 77±10 | 3±8 | ||||
| SDNN, msec | ||||||||
| Exenatide | 43±25 | 0.59 | 43±32 | 0.12 | 40±26 | 0.80 | −1.1±28 | 0.68 |
| Glargine | 50±48 | 30±13 | 38±24 | −12.1±53 | ||||
| RMSSD, msec | ||||||||
| Exenatide | 28±21 | 0.83 | 34±35 | 0.03 | 32±36 | 0.63 | 4.9±40.2 | 0.56 |
| Glargine | 31±40 | 15±6 | 27±21 | −3.3±44.4 | ||||
| LF/HF ratio | ||||||||
| Exenatide | 4.5±3.8 | 0.11 | 4.8±4.6 | 0.29 | 4.9±5.7 | 0.93 | 0.8±5.1 | 0.10 |
| Glargine | 11.1±17.2 | 6.7±6.7 | 5.0±3.6 | −6.0±17.3 | ||||
| Valsalva ratio | ||||||||
| Exenatide | 1.4±0.5 | 0.98 | 1.4±0.3 | 0.91 | 1.3±0.2 | 0.13 | −0.4±11 | 0.63 |
| Glargine | 1.3±0.3 | 1.4±0.3 | 1.4 ±0.4 | −0.19±0.9 | ||||
| E/I ratio | ||||||||
| Exenatide | 1.2±0.3 | 0.99 | 1.1±0.1 | 0.07 | 1.1 ±0.1 | 0.13 | −0.06±0.3 | 0.21 |
| Glargine | 1.2±0.3 | 1.1±0.03 | 1.1±0.04 | −0.09±0.27 | ||||
Data are presented as mean ±SD)
HR: heart rate, SDNN: standard deviation of normal RR interval, RMSSD: root mean square difference of successive RR interval, LF: low frequency power, HF: high frequency power, E:I ratio: expiration inspiration ratio.