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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Biochem Pharmacol. 2015 Sep 21;98(4):564–572. doi: 10.1016/j.bcp.2015.09.014

Figure 2.

Figure 2

NOSH-aspirin does not cause gastric damage. Aspirin and NOSH-aspirin were administered orally at equimolar doses (1 mmol/kg) and effects on the stomach were evaluated 6 hrs post-administration as indicated in Section 2.2. Panel A, shows the stomach of a vehicle-treated rat; Panel B, stomach of an aspirin-treated rat showing ulceration and bleeding; Panel C, stomach of a NOSH-aspirin-treated rat which is devoid of ulcers. Panel D, gastric damage due to aspirin, UI = 48 ± 4 mm (†P < 0.01 compared to vehicle), whereas NOSH-aspirin was gastric damage-sparing, UI = 2 ± 0.5 mm (*P < 0.01 compared to aspirin).