Table 2.
Unadjusted and Adjusted Hazard Ratios (95% Confidence Intervals) for Mortality (N=162)
Risk Factor | Unadjusted HR (95% CI) |
Adjusted HR (95% CI) |
|||||
---|---|---|---|---|---|---|---|
AC + vs. − | 1.36 (0.67, 2.76) |
1.53 (0.68, 3.44) |
- | ||||
NUC + vs. − | 0.71 (0.32,1.61) |
0.62 (0.25, 1.54) |
- | ||||
Scl-70 + vs. − | 1.85 (0.56, 6.12) |
1.27 (0.29, 5.52) |
- | ||||
Other + vs. − | 1.16 (0.44, 3.06) |
1.40 (0.52, 3.76) |
- | ||||
RNA pol + vs. − | NA* | - | |||||
U1RNP +vs. − | 0.98 (0.23, 4.12) |
1.41 (0.29, 6.88) |
- | ||||
Negative + vs. − | 0.38 (0.06, 3.03) |
- | - | - | - | - | 0.44 (0.06, 3.28) |
Age, y | 1.02 (0.98, 1.05) |
1.03 (0.99, 1.08) |
1.03 (0.99, 1.07) |
1.04 (0.99, 1.08) |
1.03 (0.99, 1.08) |
1.04 (1.00, 1.08) |
1.04 (1.00, 1.08) |
Sex, male vs. female |
1.92 (0.72, 5.08) |
1.79 (0.58, 5.49) |
1.69 (0.56, 5.05) |
1.61 (0.54, 4.81) |
1.55 (0.52, 4.61) |
1.48 (0.47, 4.59) |
1.52 (0.51, 4.51) |
Race, non-white vs. white |
1.46 (0.65, 3.27) |
1.59 (0.64, 3.95) |
1.77 (0.70, 4.49) |
1.64 (0.66, 4.10) |
1.64 (0.65, 4.10) |
1.67 (0.67, 4.21) |
1.52 (0.61, 3.82) |
SSc disease duration, y |
1.00 (0.96, 1.03) |
0.99 (0.95, 1.03) |
0.99 (0.96, 1.03) |
1.00 (0.96, 1.04) |
1.00 (0.96, 1.04) |
1.00 (0.96, 1.03) |
1.00 (0.61, 1.03) |
AC=anticentromere, NUC=nucleolar ANA, Scl-70=anti-topoisomerase I, Other=other non-specific positive ANAs, overlapping antibodies, RNA pol=RNA polymerase III.
No PHAROS patients with +RNA pol died during the follow-up period.