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. Author manuscript; available in PMC: 2016 Dec 10.
Published in final edited form as: J Control Release. 2015 Oct 9;219:2–7. doi: 10.1016/j.jconrel.2015.10.005

Table 4.

Solubility Definitions.

Descriptive Terms Parts of Solvent Required for 1
Part of Solute
Solubility Range
mg/mL %
Very soluble Less than 1 > 1,000 >100
Freely soluble From 1 to 10 100 ~ 1,000 10 ~ 100
Soluble From 10 to 30 33 ~ 100 3.3 ~ 10
Sparingly soluble From 30 to 100 10 ~ 33 1 ~ 3.3
Slightly soluble From 100 to 1,000 1 ~ 10 0.1 ~ 1
Very slightly soluble From 1,000 to 10,000 0.1 ~ 1 0.01 ~ 0.1
Practically insoluble 10,000 and over ≤0.1 ≤0.01