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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Transl Res. 2015 Jun 24;166(6):706–720.e11. doi: 10.1016/j.trsl.2015.06.008

Fig. 4. miRNA dysregulation affects multiple genes and pathways in women with VBD and VBD+IBS.

Fig. 4

miRNA dysregulation in women with VBD and VBD+IBS leads to dysregulation of genes involved in pain-relevant pathways including the TGFβ, MAPK, and Wnt signaling pathways (shown in green). Pathways that do not overlap between women with VBD and VBD+IBS represent separate pathways of vulnerability. Pathways unique to VBD (shown in blue) include the dorso-ventral axis formation, GnRH signaling and gap junction pathways. Pathways unique to VBD+IBS (shown in red) include the ECM, DRPLA and insulin resistance pathways. A considerable amount of interaction and communication is demonstrated between genes and across pathways. See Supplemental Content for abbreviations.