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Schematic illustration of a representative camptothecin drug amphiphile (DA). (A) The self-assembled nanostructures contain the same drug content as that of the individual DA. (B) Illustration of the three key components: the hydrophobic drug CPT, Tau-β-sheet-forming peptide, and the buSS biodegradable linker (or using a non-degradable amine linker). RP-HPLC trace (C) and MALDI-Tof mass spectrum (D) of the mCPT-buSS-Tau DA to reveal high purify and monodispersity in molecular mass.
