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Self-assembly of the ester-based CPT-buSS-Tau (1) and carbonate-based CPT-etcSS-Tau (2) drug amphiphiles into filamentous structures and the effect of the linker on the release mechanism of the free drug, CPT, and the subsequent cytotoxicity. Representative TEM images reveal similar morphologies assembled by the two CPT DAs that only differ in the linker design (adapted from ref. [189]).
