Figure 4. Quality-adjusted health metrics.
daf-2 mutants are healthier than wild type. (a) Quality-adjusted lifespan curves for the health metrics observed by Bansal et al.2, with each metric normalized to the maximum value of the wild type. (b) The quality-adjusted lifespan curve is the survival rate multiplied by the normalized health measurement. (c) Visualizing the cumulative area under the quality-adjusted lifespan curve at each time point shows that daf-2 mutants have higher lifespan quality over most measured health metrics. (d) Analysis of additional healthspan data measured by Huang et al.19 shows a similar increase in total lifespan quality of daf-2 mutants over wild type.