Table 1.
The relationship between the expressions of iNOS and VEGF, MVD and pathological features of gastric carcinoma
| Pathological characteristics | MVD (¯x ± s) | positive iNOS (%) | positive VEGF (%) | total |
| Site of gastric cancer lesion | ||||
| Upper one third | 61.50 ± 14.50 | 5 (62.50) | 4 (50.0) | 8 |
| Middle one third | 59.82 ± 16.54 | 8 (61.54) | 10 (76.92) | 13 |
| Lower one third | 54.52 ± 20.01 | 14 (56.00) | 21 (84.0) | 25 |
| Size of tumor | ||||
| < 3 cm | 61.50 ± 20.51 | 1 (50.0) | 2 (100.0) | 2 |
| 3-5 cm | 59.78 ± 16.58 | 11 (61.11) | 14 (77.78) | 18 |
| > 5 cm | 54.86 ± 17.99 | 15 (57.69) | 19 (73.08) | 26 |
| Depth of invasion | ||||
| Invading serosa | 62.35 ± 32.97 | 22 (64.71) | 29 (85.29)c | 34 |
| Not invading serosa | 55.15 ± 18.28 | 5 (41.67) | 6 (50.0) | 12 |
| Metastasis of lymph nodes | ||||
| Positive | 68.69 ± 18.07a | 26 (70.27)b | 31 (83.78)d | 37 |
| Negative | 54.40 ± 14.23 | 3 (33.33) | 4 (44.44) | 9 |
| Degree of differentiation* | ||||
| Well differentiated | 49.49 ± 20.10 | 10 (66.67) | 11 (73.33) | 15 |
| Poorly differentiated | 59.24 ± 16.80 | 17 (54.84) | 24 (77.42) | 31 |
Note:*Well differentiated cancer cells include highly and moderately differentiated ones; poorly differentiated cancer cells include poorly differentiated and undifferentiated ones and mucous adenocarcinoma.
a
P < 0.01 (t = 2.205), vs MVD in cases having no lymph node metastasis;
b
P < 0.05 (χ² = 6.3587), vs the rate of expression of iNOS in cases having no lymph node metastasis;
c
P < 0.05 (χ² = 6.2584), vs the rate of expression of VEGF in gastric carcinomas not invading to serosa;
d
P < 0.05 (χ2 = 6.1574), vs the rate of expression of VEGF in cases having no lymph node metastasis.