Table 4.
The relationship between the expression of Egr-1 and cell apoptosis and biological behavior in esophageal squamous cell carcinoma
| Clinicopathologic data | n | Egr-1 positive n(%) | AI(cells/mm2) |
| Age(years) | |||
| ≤ 50 | 20 | 6 (30.0) | 21.5 ± 7.9 |
| > 50 | 46 | 12 (26.1) | 24.3 ± 8.8 |
| Tumor site | |||
| Upper segment | 4 | 0 (0) | 20.4 ± 6.2 |
| Middle segment | 50 | 14 (28.0) | 23.7 ± 9.3 |
| Lower segment | 12 | 4 (33.3) | 21.5 ± 8.4 |
| Lesion’s diameter(cm) | |||
| ≤ 5 | 45 | 10 (22.2) | 22.6 ± 8.5 |
| > 5 | 21 | 8 (38.1) | 22.3 ± 9.2 |
| Differentiation degrees | |||
| GradeI | 18 | 7 (38.9) | 31.6 ± 9.3 |
| GradeII | 33 | 10 (30.3) | 28.5 ± 8.9 |
| GradeIII | 13 | 0 (0) | 7.2 ± 3.5 |
| Keratinization | |||
| Negative | 15 | 1 (6.7) | 8.6 ± 3.2 |
| Positive | 51 | 17 (33.3)a | 34.7 ± 9.4b |
| Invasive depth | |||
| Upper muscular layer | 22 | 5 (22.7) | 18.7 ± 7.5 |
| Serosa | 44 | 13 (29.5) | 26.1 ± 9.2 |
| Lymphatic metastasis | |||
| Negative | 30 | 11 (36.7) | 23.4 ± 8.6 |
| Positive | 36 | 7 (19.4) | 20.8 ± 7.5 |
| Bcl-X/L protein | |||
| Negative | 19 | 10 (52.6) | 29.4 ± 8.8 |
| Positive | 47 | 8 (17.0)c | 13.5 ± 4.2d |
a
P < 0.05, χ2 = 4.15 vs compared with non-keratinized squamous carcinoma group, χ2 test;
b
P < 0.01, t = 16.79 vs compared with non-keratinized squamous carcinoma group, Student’s t test;
c
P < 0.01, χ2 = 8.65 vs compared with Bcl-X/L protein negative group, χ2 test;
d
P < 0.01, t = 7.54 vs compared with Bcl-X/L pro-tein negative group, Student’s t test.