Table 1.
Histologic features evaluated on each slide and score scale
| Histologic features | Score | Grading |
| Chronic inflammation | 0, none | 0, none |
| 1, < 10 cic*/HPF** | 1-2-3, mild | |
| 2, > 10 cic/HPF | 4-5-6, moderate to marked | |
| 3, some areas with dense cic | ||
| 4, diffuse infiltration with dens cic | ||
| 5, nearly whole mucosa contains a dense cic | ||
| 6, entire mucosa contains a dense cic infiltrate | ||
| Inflammatory activity | 0, none | 0, none |
| 1, only one crypt involved/biopsy | 1-2, mild | |
| 2, two crypts involved/biopsy | 3-4-5-6, moderate to marked | |
| 3, many crypts (< 25%) involved/biopsy | ||
| 4, 25%-50% of crypts involved/biopsy | ||
| 5, > 50% of crypts involved/biopsy | ||
| 6, all crypts involved | ||
| Atrophy | 0, none | 0, none |
| 1, foci where a few gastric glands are lost or replaced by ie● | 1-2, mild | |
| 2, small areas in which gastric glands | 3-4-5-6, moderate to marked | |
| have disappeared or been replaced by ie | ||
| 3, < 25% of gastric glands lost or replaced by ie | ||
| 4, 25%-50% of gastric glands lost or replaced by ie | ||
| 5, > 50% of gastric glands lost or replaced by ie | ||
| 6, only a few small areas of gastric glands remaining | ||
| Intestinal metaplasia | 0, none | 0, none |
| 1, only one crypt replaced by ie | 1-2-3, mild | |
| 2, one focal area (1-4 crypts) in one of two biopsies | 4-5-6, moderate to marked | |
| 3, two separate foci | ||
| 4, multipl foci in one or both biopsies | ||
| 5, > 50% of gastric epithelium diffusely replaced by ie | ||
| 6, only a few small area of gastric epithelium are not replaced by ie | ||
| H pylori | 0, none | 0, none |
| 1, H pylori found only in one place | 1-2-3-4, mild | |
| 2, only a few H pylori found | 5-6, moderate to marked | |
| 3, scattered H pylori found in separate areas/foci | ||
| 4, numerous H pylori in separate areas/foci | ||
| 5, nearly complete gastric surface covered by a layer of H pylori | ||
| 6, continuous gastric surface coverage by a thick layer of H pylori | ||
| Surface epithelial damage | 0, none | 0, none |
| 1, slight | 1-2-3-4, mild | |
| 2, mild deg◆ in the top of the epithelial cells | 5-6, moderate to marked | |
| 3, moderate deg with disorientation of the epithelial lining | ||
| 4, indistinct cell borders at the surface of the epithelium | ||
| 5, flattened epithelial cells with severe deg and enlarged nuclei | ||
| 6, flattened to erosive epithelium of the entire surface |
*: Chronic inflammatory cells, **: High power field, ●: Intestinal type epithelium, ◆: Degeneration.