Table 5.
Complex segregation analysis on HCC among the 210 extended pedigrees (SAGE-REGTL, model 1)
| Parametera |
Hypothesis |
||||||
|
Mendelian |
Majorgene | Environmental | Notransmission | General | |||
| Dominant | Recessive | Additive | |||||
| qA | 0.00304 | 0.11138 | 0.11451 | 0.87964 | 0.02229 | 0b | 0.00861 |
| τAA | 1.0b | 1.0b | 1.0b | 1.0b | 1.0c | 0b | 1.0c |
| τAB | 0.5b | 0.5b | 0.5b | 0.5b | 1.0c | 0b | 0.0c |
| τBB | 0b | 0b | 0b | 0b | 1.0c | 0b | 1.0c |
| βAA | -5.74896 | -6.86219 | -7.30081 | -13.664 | -7.27445 | -6.74403 | -9.22295 |
| βAB | -5.74896d | -14.22974 | -14.45292 | -22.64140 | -4.14230 | -6.74403d | -6.19460 |
| βBB | -11.62577 | -14.22974d | -21.60502 | -6.83546 | -9.94049 | -6.74403d | -20.47273 |
| α | 0.10039 | 0.12335 | 0.12867 | 0.12385 | 0.07499 | 0.05710 | 0.08464 |
| γ | 0.72125 | 1.000c | 0.86915 | 1.000c | 0.89922 | 1.000c | 1.000c |
| ζHBsAg | 0.93155 | 1.36380 | 1.84008 | 1.20200 | 2.72339 | 2.70874 | 1.47535 |
| -2lnL | 831.07918 | 799.68716 | 805.17010 | 798.20661 | 822.20467 | 842.79594 | 803.24635 |
| AIC | 843.07918 | 811.68716 | 817.17010 | 812.20661 | 838.20467 | 850.79594 | 825.24635 |
| χ² | 27.83283 | 3.55919 | 1.92375 | 5.03974 | 18.95832 | 39.54959 | |
| dfe | 1-5 | 2-5 | 1-5 | 1-4 | 2-3 | 4-7 | |
| Pvalue | P < 0.001 | P > 0.1 | P > 0.1 | 0.01 < P < 0.03 | P < 0.001 | P < 0.001 | |
a: See Materials and Methods for definitions of the parameters. b: Parameter was fixed at this value and estimation was not carried out. c: Parameter estimate reached its bound. d: Parameter was constrained to equal the preceding one and was not estimated. e: Range in degrees of freedom was given since parameters in models reached their bounds.