Fig. 2.

Serum bone turnover markers during FREEDOM and the FREEDOM Extension. Concentrations of predose CTx (a) and P1NP (b) are shown. Dashed lines represent the premenopausal reference ranges: 0.20–0.90 ng/mL for CTx and 17.4–61.6 μg/L for P1NP. Data are median (interquartile range). n = number of women with observed data. Time points shown include baseline, month 1, and years 0.5, 1, 2, 3, 3 (day 10), 3.5, 4, 5, 6, 7, and 8. CTx serum C-terminal telopeptide of type 1 collagen, P1NP serum procollagen type 1 N-terminal propeptide