Fig. 4.

Incidence of nonvertebral and new vertebral fractures during FREEDOM and the FREEDOM Extension. The yearly incidence of new vertebral and nonvertebral fractures in the long-term (a, b) and cross-over (c, d) groups are shown. For new vertebral fractures, percentages are crude incidence; lateral radiographs (lumbar and thoracic) were not obtained at Extension years 1 and 4 (long-term denosumab treatment years 4 and 7); n = number of women with ≥1 fracture; N = number of women with a spine X-ray evaluation during the time period of interest. ^aAnnualized incidence (2-year incidence/2). For nonvertebral fractures, percentages are Kaplan-Meier estimates; n = number of women with ≥1 fracture; N = number of women who were still on study at the beginning of each period