Table 1.
Summary of the breast tumor molecular subtypes
Intrinsic subtype | IHC status | Grade | Outcome | PrevalenceΔ |
---|---|---|---|---|
Luminal A* | [ER+|PR+] HER2-KI67- | 1|2 | Good | 23.7% [p1] [10] |
Luminal B* | [ER+|PR+] HER2-KI67+ | 2|3 | Intermediate | 38.8% [p1] [10] |
[ER+|PR+] HER2+KI67+ | |Poor | 14% [p1] [10] | ||
HER2 over-expression* | [ER-PR-] HER2+ | 2|3 | Poor | 11.2% [p1] [10] |
Basal* | [ER-PR-] HER2-, basal marker+ | 3 | Poor | 12.3% [p1] [10] |
Normal-like | [ER+|PR+] HER2-KI67- | 1|2|3 | Intermediate | 7.8% [p2] [15] |
Subtypes with detailed expression patterns and clinical implications discussed in the text, which take the majority of the breast tumor cases and are most commonly referred to.
The prevalence of each subtype is taken from the publication indicated in the square bracket.