Table 2.

Frequency distributions of CHRNA5 alleles and their associations with lung cancer risk in smokers

SNP ID	Position	Alleles	MAF		H-W p-value	Without adjustment			With adjustment
		Aa/B	case	control		ORs	95% CI	Allele p b	ORs	95% CI	Allele p c
rs10519205	78878791	C/T	0.061	0.038	0.703	1.623	0.673-3.916	0.277	1.371	0.510-3.687	0.532
rs12903839	78867042	G/C	0.009	0.005	0.958	1.671	0.172-16.180	0.939	0.725	0.104-5.070	0.746
rs16969948	78864786	G/A	0.064	0.038	0.703	1.699	0.708-4.077	0.230	1.384	0.516-3.713	0.519
rs17408276	78881618	C/T	0.235	0.167	0.255	1.532	0.959-2.448	0.073	1.741	1.013-2.991	0.045*
rs17486278	78867482	C/A	0.282	0.306	0.233	0.892	0.599-1.327	0.572	0.837	0.532-1.316	0.440
rs495956	78869930	G/A	0.280	0.187	0.208	1.697	1.089-2.645	0.019*	1.856	1.116-3.086	0.017*
rs601079	78869579	A/T	0.291	0.198	0.342	1.664	1.077-2.571	0.021*	1.787	1.086-2.940	0.022*
rs680244	78871288	A/G	0.291	0.194	0.282	1.700	1.096-2.636	0.017*	1.834	1.110-3.030	0.018*
rs7180002	78873993	T/A	0.033	0.044	0.661	0.750	0.296-1.900	0.543	0.687	0.238-1.985	0.488
rs951266	78878541	T/C	0.033	0.049	0.620	0.663	0.269-1.631	0.368	0.629	0.225-1.759	0.377
rs16969968	78882925	A/G	0.042	0.044	0.661	0.964	0.396-2.342	0.935	1.022	0.370-2.820	0.967
rs1875869	78868157	T/A	0.064	0.038	0.703	1.699	0.708-4.077	0.230	1.384	0.516-3.713	0.519
rs667282	78863472	C/T	0.430	0.500	0.753	0.755	0.525-1.086	0.130	0.759	0.502-1.147	0.190
rs11637635	78877150	A/G	0.215	0.143	0.328	1.645	1.006-2.688	0.046*	1.975	1.120-3.485	0.019*
rs12903575	78881087	A/G	0.009	0.011	0.915	0.817	0.135-4.932	0.803	1.213	0.113-13.012	0.873
rs16969949	78866964	T/C	0.064	0.038	0.703	1.699	0.708-4.077	0.230	1.384	0.516-3.713	0.519
rs684513	78858400	G/C	0.227	0.313	0.971	0.645	0.430-0.968	0.033*	0.652	0.411-1.035	0.070
rs2277550	78858263	A/C	0.015	0.022	0.830	0.685	0.181-2.582	0.833	0.473	0.100-2.231	0.344
rs555018	78879242	C/T	0.227	0.154	0.496	1.618	1.003-2.609	0.047*	1.883	1.086-3.263	0.024*
rs588765	78865425	T/C	0.227	0.154	0.496	1.618	1.004-2.609	0.047*	1.883	1.086-3.263	0.024*
rs7178897	78862975	C/T	0.061	0.038	0.845	1.623	1.005-3.916	0.277	1.266	0.466-3.442	0.644
rs692780	78876505	G/C	0.236	0.159	0.035#	–	–	–	–	–	–

^aMinor allele.

^b p values were calculated from two-sided chi-square tests or Fisher’s exact tests for either allele frequency.

^c p values were calculated by unconditional logistic regression adjusted for age and sex.

^* p value ≤ 0.05 indicates statistical significance.

^#site with HWE p ≤ 0.05 is excluded.

CI, confidence interval; HWE, Hardy-Weinberg Equilibrium; MAF, minor allele frequency; ORs, odds ratios; SNP, single nucleotide polymorphism.