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. 2015 Sep 15;5(10):3249–3259.

Table 1.

The selected functional SNPs in 10 apoptosis-related genes and their allele frequencies

Gene Chromosome Location Position SNP Allele* MAF (CHB) MAF (observed)
TP53 17p13.1 exon 4 7579472 rs1042522 G/C 0.489 0.413
TP53INP1 8q22 3’UTR (miR-330-5p target site) 95938422 rs7760 G/T 0.109 0.113
TP53BP1 15q15-q21 promoter 43803621 rs1869258 T/G 0.489 0.452
exon 9 43767774 rs560191 C/G 0.444 0.424
exon 17 43724646 rs2602141 G/T 0.478 0.425
CDKN2A 9p21 exon 3 21968199 rs11515 C/G 0.011 0.022
exon 3 21968159 rs3088440 T/C 0.107 0.123
CDKN1A 6p21.2 exon 2 36651971 rs1801270 A/C 0.449 0.488
3’UTR 36653597 rs1059234 T/C 0.442 0.496
CDKN1B 12p13.1-p12 promoter 12869936 rs36228499 A/C 0.408 0.414
promoter 12870695 rs34330 T/C 0.470 0.461
exon 1 12871099 rs2066827 G/T 0.044 0.022
MDM2 12q14.3-q15 promoter 69202580 rs2279744 T/G 0.358 0.465
BAX 19q13.3-q13.4 promoter 49457938 rs4645878 A/G 0.051 0.068
CCND1 11q13 exon 4 69462910 rs603965 (rs9344) G/A 0.438 0.422
BCL2 18q21.3 P2 promoter (5’flanking) 60986837 rs2279115 A/C 0.433 0.411

Abbreviations: MAF, minor allele frequency; CHB, Chinese Han in Beijing.

*

Minor allele/major allele.

Obtained from the International Hap Map Project database (http://hapmap.ncbi.nlm.nih.gov/).

Estimated from 362 HCC patients receiving surgical resection of the tumor.