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. 2015 Sep 15;5(10):3249–3259.

Table 3.

Univariate and multivariate Cox regression analysis of genotype of all selected SNPs in 362 HCC patients with surgical resection for the tumor

Genotype No of patients No of events 5-y-survival (%) MST (95% CI) Overall survival
Univariate analysis Multivariate analysis
Hazard ratio (95% CI) P Hazard ratio (95% CI) P
TP53_rs1042522
    GG 114 73 30 36.0 (25.8-46.2) 1.000 1.000
    GC 191 114 32 30.0 (22.1-37.9) 0.960 (0.715-1.288) 0.785 0.967 (0.720-1.300) 0.825
    CC 52 33 26 51.0 (38.5-63.5) 0.910 (0.603-1.374) 0.654 0.899 (0.590-1.371) 0.622
    CC+GC 243 147 30 35.0 (23.2-46.8) 0.950 (0.717-1.258) 0.719 0.946 (0.713-1.255) 0.699
TP53INP1_rs7760
    TT 279 178 28 31.0 (23.5-38.5) 1.000 1.000
    GT 75 44 32 41.0 (25.0-57.0) 0.838 (0.602-1.166) 0.294 0.875 (0.628-1.218) 0.428
    GG 3 2 33 16.0 (0.0-33.6) 1.244 (0.309-5.018) 0.759 1.467 (0.361-5.956) 0.592
    GG+GT 78 46 32 38.0 (21.7-54.3) 0.850 (0.614-1.176) 0.326 0.891 (0.643-1.233) 0.485
TP53BP1_rs1869258
    TT 112 62 38 46.0 (23.0-69.0) 1.000 1.000
    GT 172 112 26 35.0 (25.4-44.6) 1.223 (0.897-1.669) 0.204 1.214 (0.887-1.659) 0.225
    GG 77 50 27 30.0 (20.9-39.1) 1.263 (0.870-1.834) 0.220 1.307 (0.899-1.902) 0.161
    GG+GT 249 162 26 33.0 (26.7-39.3) 1.239 (0.924-1.660) 0.152 1.249 (0.930-1.677) 0.140
TP53BP1_rs560191
    GG 127 70 38 46.0 (25.5-66.5) 1.000 1.000
    CG 163 107 24 36.0 (26.1-45.9) 1.260 (0.932-1.704) 0.133 1.264 (0.933-1.713) 0.130
    CC 72 48 26 30.0 (19.2-40.8) 1.161 (0.966-1.396) 0.112 1.176 (0.978-1.415) 0.085
    CC+CG 235 155 25 33.0 (26.7-39.3) 1.288 (0.971-1.708) 0.080 1.303 (0.980-1.732) 0.068
TP53BP1_rs2602141
    TT 126 69 39 46.0 (25.7-66.3) 1.000 1.000
    GT 162 107 24 35.0 (25.3-44.7) 1.282 (0.947-1.736) 0.108 1.284 (0.946-1.742) 0.108
    GG 72 48 26 30.0 (19.2-40.8) 1.357 (0.938-1.963) 0.105 1.393 (0.961-2.019) 0.080
    GG+GT 234 155 25 33.0 (26.7-39.3) 1.306 (0.983-1.736) 0.065 1.320 (0.992-1.757) 0.057
CDKN2A_rs11515
    CC 344 213 30 35.0 (29.0-41.0) 1.000 1.000
    GC 16 11 31 12.0 (0.0-27.7) 1.312 (0.715-2.406) 0.381 1.382 (0.752-2.540) 0.298
    GG 0 0
CDKN2A_rs3088440
    CC 277 173 29 33.0 (26.1-39.9) 1.000 1.000
    CT 79 48 32 36.0 (21.8-50.2) 0.922 (0.660-1.269) 0.617 0.964 (0.699-1.330) 0.825
    TT 5 4 12 61.0 (35.2-86.8) 0.844 (0.313-2.277) 0.738 0.860 (0.318-2.325) 0.767
    TT+CT 84 52 30 39.0 (25.3-52.7) 0.915 (0.671-1.247) 0.574 0.955 (0.699-1.304) 0.771
CDKN1A_rs1801270
    AA 97 55 36 36.0 (12.0-60.0) 1.000 1.000
    CA 177 115 27 35.0 (29.1-40.9) 1.215 (0.881-1.676) 0.236 1.170 (0.846-1.617) 0.342
    CC 88 55 28 28.0 (11.1-44.9) 1.270 (0.873-1.848) 0.211 1.193 (0.817-1.742) 0.361
    CC+CA 265 170 27 33.0 (26.0-40.0) 1.230 (0.907-1.667) 0.183 1.186 (0.873-1.610) 0.275
CDKN1A_rs1059234
    CC 93 59 28 27.0 (11.4-42.6) 1.000 1.000
    TC 179 115 27 37.0 (31.1-42.9) 0.937 (0.684-1.283) 0.685 0.924 (0.673-1.267) 0.623
    TT 90 51 37 35.0 (11.4-58.6) 0.783 (0.538-1.140) 0.202 0.842 (0.575-1.233) 0.377
    TT+TC 269 166 30 36.0 (29.5-42.5) 0.883 (0.656-1.188) 0.411 0.893 (0.662-1.204) 0.457
CDKN1B_rs36228499
    CC 127 74 34 33.0 (21.1-44.9) 1.000 1.000
    CA 170 109 28 37.0 (28.1-45.9) 1.080 (0.804-1.451) 0.609 1.045 (0.776-1.406) 0.773
    AA 65 42 26 30.0 (16.5-43.5) 1.147 (0.785-1.675) 0.479 1.082 (0.739-1.585) 0.685
    AA+CA 235 151 27 35.0 (28.1-41.9) 1.101 (0.834-1.455) 0.497 1.062 (0.803-1.405) 0.672
CDKN1B_rs34330
    TT 110 66 33 31.0 (20.7-41.2) 1.000 1.000
    CT 169 105 29 38.0 (28.8-47.2) 0.946 (0.695-1.287) 0.723 0.907 (0.666-1.237) 0.539
    CC 82 54 27 24.0 (15.5-32.5) 1.176 (0.820-1.685) 0.378 1.108 (0.771-1.593) 0.578
    CC+CT 251 159 28 37.0 (29.3-44.7) 1.019 (0.764-1.357) 0.900 0.975 (0.731-1.300) 0.862
CDKN1B_rs2066827
    TT 346 215 30 35.0 (28.2-41.8) 1.000 1.000
    GT 16 10 26 33.0 (12.9-53.1) 1.093 (0.579-2.060) 0.784 0.992 (0.524-1.877) 0.981
    GG 0 0
MDM2_rs2279744
    GG 103 60 32 39.0 (23.6-54.4) 1.000 1.000
    GT 179 112 28 35.0 (26.2-43.8) 1.082 (0.791-1.481) 0.622 1.070 (0.779-1.468) 0.677
    TT 78 51 32 28.0 (15.2-40.8) 1.118 (0.769-1.626) 0.558 1.157 (0.790-1.694) 0.454
    TT+GT 257 163 29 31.0 (24.6-37.4) 1.092 (0.812-1.468) 0.561 1.094 (0.811-1.474) 0.577
BAX_rs4645878
    GG 313 190 32 34.0 (26.2-41.8) 1.000 1.000
    GA 49 35 14 37.0 (28.3-45.7) 1.197 (0.834-1.717) 0.329 1.200 (0.834-1.725) 0.326
    AA 0 0
CCND1_ rs9344
    AA 121 80 23 35.0 (26.2-43.8) 1.000 1.000
    GA 175 101 36 39.0 (25.5-52.5) 0.852 (0.635-1.144) 0.287 0.893 (0.663-1.202) 0.455
    GG 65 44 23 24.0 (16.3-31.7) 1.110 (0.923-1.335) 0.266 1.085 (0.900-1.308) 0.392
    GG+GA 240 145 32 34.0 (25.7-42.3) 0.941 (0.716-1.237) 0.664 0.965 (0.733-1.271) 0.802
BCL2_rs2279115
    CC 126 75 31 37.0 (27.7-46.3) 1.000 1.000
    CA 173 110 30 31.0 (17.3-44.7) 1.067 (0.795-1.431) 0.666 1.043 (0.777-1.401) 0.778
    AA 62 39 28 31.0 (23.6-38.4) 1.109 (0.752-1.634) 0.602 1.124 (0.759-1.665) 0.559
    AA+CA 235 149 30 31.0 (23.4-38.6) 1.076 (0.815-1.420) 0.606 1.058 (0.801-1.398) 0.691

Abbreviations: MST, median survival time; CI, confidence interval.