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. 2015 Oct 15;7(10):1765–1781.

Figure 6.

Figure 6

A. FL118 exhibits superior ability to inhibit survivin, Mcl-1, XIAP, or cIAP2 than topotecan. Subconfluent FaDu and SW620 cancer cells were treated with FL118 or topotecan as shown. Cells were then analyzed for FL118 target gene expression using western blots. Actin was used as an internal control for protein loading. B. Expression of MDR1 and ABCG2 in colon cancer cells. Subconfluent SW620, HCT-8 and HCT-116 cancer cells were lysed and analyzed for the expression of MDR1 and ABCG2 using western blots. Actin is the internal control. C. Comparison of the effectiveness of SN-38, topotecan and FL118 in cancer growth inhibition and killing. Subconfluent SW620 cancer cells were treated with SN-38, topotecan and FL118 for 72 hours at 1 µM as shown. Representative cancer cell images were shown.