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FL118 but not SN-38 can inhibit colon caner cell growth in a relative low concentration
| Determined in SW620 cells | Determined in HCT-8 cells | |||||
|---|---|---|---|---|---|---|
|
|
||||||
| SN-38 | FL118 | SN-38/FL118 | SN-38 | FL118 | SN-38/FL118 | |
| IC25 | ND | ND | NA | 0.187 | 0.047 | 3.958 |
| IC50 | 14.55 | 5.867 | 2.48 | 4.229 | 0.529 | 7.994 |
| IC75 | 157.5 | 12.53 | 12.57 | 95.80 | 5.95 | 16.10 |
| IC90 | 1795.5 | 27.00 | 66.50 | 2172.2 | 66.80 | 32.52 |
| IC95 | 3811.5 | 45.33 | 84.08 | 18143.4 | 346.11 | 52.42 |
