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FL118 is highly permeable in Caco-2 permeability assay and not a P-gp substrate
| Test Article | Direction | Recovery (%) | Papp value (10-6 cm/s) | Efflux Ratio | ||
|---|---|---|---|---|---|---|
|
| ||||||
| R1* | R2 | AVG | ||||
| FL118 (1 µM) | A-to-B | 43 | 7.27 | 6.67 | 6.97 | 1.2 |
| B-to-A | 48 | 7.35 | 8.86 | 8.10 | ||
| FL118 (1 µM) + Valspodar (1 µM) | A-to-B | 46 | 9.26 | 7.48 | 8.37 | 1.0 |
| B-to-A | 48 | 8.29 | 8.65 | 8.47 | ||
Papp: apparent permeability; R1: replicate 1; R2: replicate 2; AVG: average.
