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Comparison of IC50 of FL118 to SN-38 with and without ATP-binding cassette transporter inhibitors
| Drugs | Cell Types | No inhibitor | Ko143 | Sildenafil |
|---|---|---|---|---|
| FL118 (nM) | SW620 | 0.54 | 0.45 | 0.36 |
| HCT-8 | 0.67 | 0.58 | 0.59 | |
| SN-38 (nM) | SW620 | 10.07 | 3.78 | 1.25 |
| HCT-8 | 8.92 | 3.82 | 1.15 |
