Figure 3.

Mutations of ATRX in leiomyosarcomas. (A) The distribution of ATRX mutations in leiomyosarcomas. Two patients had the p.G1589* mutation. *: stop codon; FS: Frameshift mutation; CC: Coiled-coil domain; NLS: Nulcear localization signal; E: Negative tract; P: P domain; Q: Q domain. (B) Kaplan-Meier survival analyses of patients with ATRX-mutated and ATRX-wild-type leiomyosarcomas. (C) Immunostaining demonstrated the loss of ATRX expression in a leiomyosarcoma. (D) Telomere-specific fluorescent in situ hybridization revealed the presence of large and bright signals. (C) and (D) were taken from a case with ATRX mutation.