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. 2015 Oct 15;7(10):2115–2126.

Figure 6.

Figure 6

miR-155 stimulates STAT3 signaling in breast cancer cells by inhibiting SOCS6. A. miR-155 actived STAT3 signal pathway by targeting SOCS6. MCF7 and SKBR3 cells were tranfected with miR-155 combined with SOCS6 or its control and total protein was extracted from the cells for western blot analysis. Three independent experiments were performed. B. Qutification of protein bands from MCF-7/TAM cells (A). C. Qutification of protein bands from SKBR3/TAM cells. D. STAT3 inhibitor, JSI-124 suppressed miR-155 induced STAT3 activation in MCF-7/TAM and SKBR3/TAM cells. E. STAT3 inhibitor, JSI-124 suppressed STAT3 activation and inhibited miR-155 induced MCF-7 cell proliferation. F. JSI-124 suppressed STAT3 activation and inhibited miR-155 induced SKBR3 cell proliferation. Three independent experiments were performed. Data is represented as mean ± SE of three independent experiments. **p<0.01; *p<0.05.