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. 2015 Nov 17;17(10):789–803. doi: 10.1016/j.neo.2015.10.003

Figure 1.

Figure 1

P53 mutant expression plasmid vectors were created for mutants in serous ovarian carcinomas with high evolutionary impact scores. (A) Calculated biological impact data (EA score) for p53 missense mutations in ovarian tumor samples (data from TCGA). Out of 464 samples, 83% had p53 mutations (385). Of these, 233 were missense mutations (black and gray) and 99 are unique (black). (B) All p53 hot-spot mutations in ovarian tumor samples (TCGA) are predicted to have biologic function. One hundred ten ovarian tumors have 1 of the 14 hot-spot mutations defined as mutations that appear in more than 1% of the ovarian tumors in TCGA. (C) All of the hot-spot mutations are located in the DNA-binding domain.