Table 1.

Genetically Engineered Nf1 Mouse Models.

Short Form	Genotype	Cell Type	Description	Time Point	CNS Abnormality	References
WT	Nf1flox/flox	Every cell	Exons 31 and 32 of the Nf1 gene flanked by loxP sites		None	Zhu et al., 2001
FM	Nf1flox/mut	Every cell	Reduced Nf1 gene expression		No glioma
FMC	Nf1flox/mut; GFAP-Cre	Neuroglial progenitors Surrounding cells	Complete Nf1 loss Reduced Nf1 gene expression	E14.5	Optic glioma	Bajenaru et al., 2003
FMC*	Nf1flox/mut; GFAP-Cre	Neuroglial progenitors	Complete Nf1 loss	E11.5	Optic glioma	Hegedus et al., 2008
Surrounding cells	Reduced Nf1 gene expression
FMPC	Nf1flox/mut; Pten flox/wt; GFAP-Cre	Neuroglial progenitors	Complete Nf1 loss and Pten +/−	E14.5	Optic glioma	Kaul et al., 2014
Surrounding cells	Reduced Nf1 gene expression