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. 2015 Nov 24;9:77. doi: 10.3389/fncir.2015.00077

Figure 6.

Figure 6

Changes in LGN activity by intravitreal injection of the ON- pathway inhibitor L-AP4. (A,B) Representative immunostainings to illustrate the location of c-Fos positive nuclei when L-AP4 is injected in the left eye vitreal chamber (2 mM). (A) The effect of L-AP4 on the pattern of c-Fos activation in the ipsilateral (L) or contralateral (R) LGN for an animal kept in darkness. (B) An exemplar LGN section to illustrate the clear enhancement by the mGluR6 agonist L-AP4 of the light induced response by ON-OFF light activation. Notice how the c-Fos activation of the IGL remains unaffected by the drug. This presumably reflects the predominant input from melanopsin-containing intrinsically photosensitive retinal ganglion cells in the non-image forming pathway (Güler et al., 2007). Small panels on the right are magnification of the dLGN, IGL, and vLGN from the corresponding sections. Calibration bar is 200 μm for the large immunostaining panels and 50 μm for the small insets.