Table 5.
Brain response abnormalities in ALS compared to HCs in task of right-hand movement execution.
| Region | MNI coordinate (x, y, z) | SDM-Z | P-values | Voxels | Clusters of breakdown (no. of voxels) | Jackknife sensitivity analysis |
|---|---|---|---|---|---|---|
| Hyperactivity in als patients compared to HCs | ||||||
| Left postcentral gyrus, BA 3 | −34, −38, 54 | 3.134 | 0.000010312 | 1798 | L postcentral gyrus (666) | 7 out of 8 |
| L precentral gyrus (337) | ||||||
| L paracental lobule (273) | ||||||
| L prcuneus (81) | ||||||
| L inferior parietal (47) | ||||||
| L hand superior U tract (43) | ||||||
| L superior parietal gyrus (31) | ||||||
| L superior longitudinal fasciculus II (20) | ||||||
| Corpus callosum (290) | ||||||
| Undefined (10) | ||||||
| Corpus callosum | 10, 6, 52 | 2.442 | 0.000190973 | 1932 | R SMA (536) | 3 out of 8 |
| R median cingulate/paracingulate gyri (234) | ||||||
| L SMA (678) | ||||||
| L median cingulate/paracingulate gyri (329) | ||||||
| L superior fontal gyrus, medial (26) | ||||||
| L median network, cingulum (10) | ||||||
| Corpus callosum (109) | ||||||
| Other (10) | ||||||
| Right precentral gyrus, BA 4 | 36, −22, 54 | 3.037 | 0.000020623 | 1593 | R precentral gyrus (909) | 8 out of 8 |
| R postcentral gyrus (357) | ||||||
| R superior frontal gyrus, dorsolateral (74) | ||||||
| R middle frontal gyrus (69) | ||||||
| R supramarginal gyrus (33) | ||||||
| R superior longitudinal fasciculus II (29) | ||||||
| R frontal superior longitudinal (16) | ||||||
| R paracentral lobule (11) | ||||||
| Corpus callosum (73) | ||||||
| Other/undefined (22) | ||||||
| Left striatum | −20, 2, −4 | 1.895 | 0.002002418 | 46 | L striatum (31) | 5 out of 8 |
| Other/undefined (15) | ||||||
| Hypoactivity in als patients compared to HCs | ||||||
| Left precentral gyrus, BA 6 | −38, −8, 62 | −1.093 | 0.000087738 | 750 | L precentral gyrus (436) | 7 out of 8 |
| L postcentral gyrus (197) | ||||||
| L superior fontal gyrus, dorsolateral (67) | ||||||
| Corpus callosum (41) | ||||||
| Other/undefined (9) | ||||||
ALS, amyotrophic lateral sclerosis; BA, Brodmann; HC, healthy control; MNI, Montreal Neurological Institute; SDM, signed differential mapping; SMA, supplementary motor area.