Table 6.
Brain response abnormalities in ALS compared to HCs in task of right-hand movement imagery or observation.
| Region | MNI coordinate (x, y, z) | SDM-Z | P-values | Voxels | Clusters of breakdown (no. of voxels) | Jackknife sensitivity analysis |
|---|---|---|---|---|---|---|
| Hyperactivity in ALS patients compared to HCs | ||||||
| Right postcentral gyrus, BA 4 | 48, −20, 44 | 2.121 | 0.000185788 | 719 | R postcentral gyrus (357) | 3 out of 5 |
| R suparamarginal gyrus (272) | ||||||
| R precentral gyrus (56) | ||||||
| R inferior parietal gyri (27) | ||||||
| Other (7) | ||||||
| Left superior frontal gyrus, dorsolateral, BA 6 | −22, −6, 56 | 1.746 | 0.001243770 | 73 | L superior fontal gyrus, dorsolateral (26) | 0 out of 5 |
| L precentral gyrus (22) | ||||||
| Other (25) | ||||||
| Right insula, BA 48 | 34, −8, 14 | 1.684 | 0.001770139 | 69 | R insula (39) | 1 out of 5 |
| Other/undefined (30) | ||||||
ALS, amyotrophic lateral sclerosis; BA, Brodmann; HC, healthy control; MNI, Montreal Neurological Institute; SDM, signed differential mapping.