Figure 7.

Comparison of SCN cellular network model across genotype, age, and pharmacological perturbation (corresponding to Fig. 5). (a–c) Simulated clock mRNA levels in the SCN network of WT mouse (α = 0.3, K = 1). (a and c) Neonates (ψ = 0); (b) adults (ψ = 1). (Dashed line in c) Time at which the coupling was lowered from K = 1 to K = 0.4 simulating administration of tetrodotoxin. (d–f) The corresponding clock mRNA levels in the SCN network of a Cry1^−/−/Cry2^−/− mouse (α = 0, K = 1). The neonate (ψ = 0) is shown in (d) and (f) and adults (ψ = 1) in (f). To see this figure in color, go online.