Figure 14.

Lowering of the reducing capacity (GSH ratio) from Fig. 13 during 1 Hz pacing with myocyte stretching for 200 ms before each stimulus leads to increased [ROS] and increased Ca²⁺ release. (A–D) Comparison of (A) peak P_o, (B) peak [Ca²⁺]_i, (C) the corresponding fraction of channels (FoC) in mode 2 (open, closed, and inactivated), and (D) peak [Ca²⁺]_NSR at each beat. (E and F) Presence of (E) [ROS]_ds and (F) [ROS]_i in the myocyte due to cyclic stretching and release of stretch. To see this figure in color, go online.