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. 2015 Nov 17;109(10):2037–2050. doi: 10.1016/j.bpj.2015.09.031

Figure 4.

Figure 4

ROS dynamics during the stretching protocol used in Fig. 3. (A) Concentration of ROS in the myoplasm ([ROS]i). (B) Concentration of ROS in the dyadic subspace ([ROS]ds) compared to [ROS]i. (C) ROS production flux. (D) Rate of ROS activation of DCF. (E) Total concentration of activated DCF. The myocyte is stretched continuously from 10 to 20 s. (F) The rate of ROS production is adaptive (blue) rather than constant (red). Black dashed lines in (E) and (F) show experimental data from Prosser et al. (11). To see this figure in color, go online.