Table 1.

Parameters

Parameter	Definition	Value	Reference
$k{1}^{+}$	association rate constant for RyR2 and Ca2+ in mode2	24 μM−η s−1	(5)
$k{1}^{-}$	dissociation rate constant for RyR2 and Ca2+ in mode2	250 s−1	(5)
$k{2}^{+}$	oxidizing rate constant of RyR2 by ROS	1 μM−β s−1	(16)
$k{2}^{-}$	reducing rate constant of RyR2	14 s−1	(11)
β	dependence of RyR2 oxidation by ROS	0.4	(11)
$V_{\text{ds}}^{\text{T}}$	total subspace volume	0.027 pL	(14, 15)
$V_{\text{myo}}$	myoplasmic volume	18 pL	(15)
$v_{\text{ROSEfflux}}^{\text{T}}$	total rate of ROS efflux out of subspace	0.3125 s−1	(11)
$v_{\text{ROSReduction}}$	rate of ROS removal	2 s−1	(11)
${\text{time}}_{\text{ROSEnd}}$	time taken for stretch-induced ROS production to cease after release of stretch	0.6 s	(11)
$v_{\text{ROSDCF}}$	rate of DCF activation by ROS	0.85 s−1	(11)