TABLE 2.
Biochemical markers at baseline and 4 wk in girls aged 9–11 y randomly assigned to ZN or CON groups1
| ZN group (n = 75) |
CON group (n = 72) |
||||||
| Baseline | 4 wk | Change | Baseline | 4 wk | Change | P-interaction2(time x group effect) | |
| Plasma zinc, μmol/L | 12.0 (11.3, 12.8) | 13.8 (12.8, 14.7) | 1.8 (1.0, 2.6) | 12.1 (11.3, 12.9) | 12.3 (11.3, 13.3) | 0.2 (−0.3, 0.7) | <0.01 |
| Ceruloplasmin activity, IU/L | 92.1 (86.9, 97.4) | 94.8 (88.6, 101) | 2.7 (−2.8, 8.2) | 87.3 (81.9, 92.7) | 91.7 (85.3, 98.1) | 4.4 (−1.0, 9.9) | 0.65 |
| Plasma IGF-I, μg/L | 415 (359, 471) | 458 (389, 526) | 42.8 (−8.1, 93.4) | 400 (343, 457) | 422 (352, 493) | 22.1 (−11.8, 55.8) | 0.51 |
| Serum P1NP, μg/L | 704 (648, 759) | 728 (669, 786) | 23.8 (−14.9, 62.5) | 709 (652, 766) | 678 (617, 739) | −31.0 (−66.4, 4.2) | 0.039 |
| Serum osteocalcin, μg/L | 32.0 (29.9, 34.1) | 32.5 (30.2, 34.8) | 0.5 (−0.8, 1.7) | 33.3 (31.2, 35.5) | 34.5 (32.2, 36.9) | 1.2 (−0.1, 2.4) | 0.40 |
| Serum ICTP, μg/L | 24.2 (22.3, 26.1) | 24.5 (22.4, 26.7) | 0.3 (−1.3, 2.0) | 24.7 (22.7, 26.7) | 24.8 (22.5, 27.0) | 0.1 (−1.7, 1.8) | 0.83 |
| Urinary PYD/C, nmol/mmol | 102 (92.6, 111) | 102 (93.4, 110) | 0.1 (−6.7, 6.5) | 98.6 (89.3, 108) | 101 (92.7, 110) | 2.7 (−5.7, 11.1) | 0.62 |
| Urinary DPD/C, nmol/mmol | 29.6 (27.3, 32.0) | 30.4 (27.9, 32.9) | 0.8 (−1.6, 3.0) | 29.6 (27.2, 32.0) | 30.5 (27.8, 33.0) | 0.9 (−1.5, 3.3) | 0.98 |
1
Values are means (95% CIs). CON, control; DPD/C, deoxypyridinoline/creatinine; ICTP, carboxy-terminal telopeptide of type 1 collagen; IGF-I, insulin-like growth factor I; P1NP, procollagen type 1 amino-terminal propeptide; PYD/C, pyridinoline/creatinine; ZN, zinc.
2
Tests of significance for group differences in change from baseline to 4 wk were conducted by using intention-to-treat mixed-model repeated-measures ANOVA.