Table 2.
The effects of long-term administration of Vitex agnus castus ethanolic extract (VAC8 and 80 mg/kg) and estradiol valerat (40 μg/kg) on passive avoidance task in the ovariectomized rats.
| Control | VAC 80 | VAC 8 | Estradiol valerat | |
|---|---|---|---|---|
| Initial latency | 10.1± 1 | 9.3±1.4 | 9.3±1.3 | 9.7±1 |
| Step through latency (STL) | 28.1±1.6 | 184.3±31.9* | 178.8±15.2* | 220.8±2.2* |
| Time in dark chamber (TDC) | 58.5±4.9 | 31.1±4.5# | 34.5±2.3# | 24.6±1.7# |
| Shock number | 7.5±0.6 | 4±0.7$ | 5.3±0.4 | 2.6±0.3$ |
*
Significant differences in STL between VAC80, VAC8 and estradiol valerat with control group. All P<0.001.
#
Significant differences in TDC between VAC80, VAC8 and estrogen with control group. All P<0.001.
$
Significant differences in shock number between VAC80 and estrogen with control group. All P<0.001. Data expressed as mean±SEM of six animals. Control; group that received saline, VAC80 and VAC8; groups that receive 80 and 8 mg/kg VAC respectively, estrogen; group that received estradiol. All groups were ovariectomized.