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. 2015 Nov 24;5:17122. doi: 10.1038/srep17122

Figure 5. Alternative conformations of the CDK12 C-terminal extension.

Figure 5

(a) Superposition of the two CDK12715–1052 subunits in the asymmetric unit (PDB ID: 4CXA). An asterisk marks the point at which the two chains diverge following Leu1025. In chain A (green and bright pink), the C-terminal extension folds in front of the ATP pocket, whereas in chain C (gray and pale pink) the C-terminus extends across the back of the kinase domain. (b) Superposition reveals that the αK helix is stably formed in both chains despite their alternative packing arrangements. (c) Molecular surface representation of chains A and B highlighting the enclosure of the bound AMP-PNP molecule by the C-terminal kinase extension. Coloured as in Fig. 2. (d) Selected interactions of the C-terminal kinase extension packing at the front of the ATP pocket (CDK12 chain A).