Table 3. Comparison of the diagnostic value of TIRADS, BSRTC and BRAFV600E mutation Analysis.
| Statistics | TIRADS | BSRTC | BRAFV600Emutation | TIRADS + BSRTC | BSRTC + BRAFV600Emutation | TIRADS + BSRTC + BRAFV600Emutation |
|---|---|---|---|---|---|---|
| Sensitivity (95% CI) | 73.1 (64.8–80.4) | 77.6 (69.6–84.4) | 85.1 (77.9–90.6) | 92.5 (86.7–96.4) | 97.8 (93.6–99.5) | 98.5 (94.7–99.8) |
| Specificity (95% CI) | 88.4 (79.7–94.3) | 97.7 (91.9–99.7) | 100.0 (95.8–100.0) | 86.1 (76.9–92.6) | 97.7 (91.9–99.7) | 86.1 (76.9–92.6) |
| PPV (95% CI) | 90.7 (83.6–95.5) | 98.1 (93.4–99.8) | 100.0 (96.8–100.0) | 91.2 (85.1–95.4) | 98.5 (94.7–99.8) | 91.7 (85.9–95.6) |
| NPV (95% CI) | 67.9 (58.3–76.4) | 73.7 (64.6–81.5) | 81.1 (72.3–88.1) | 88.1 (79.1–94.2) | 96.6 (90.2–99.3) | 97.4 (90.7–99.7) |
| AUC (95% CI) | 0.808 (0.749–0.857) | 0.876 (0.826–0.917) | 0.925 (0.882–0.956) | 0.893 (0.844–0.930) | 0.977 (0.948–0.993) | 0.923 (0.879–0.954) |
Abbreviations: PPV, positive predictive value; NPV, negative predictive value; AUC, area under curve; CI, confidence interval.